Continuous treatment with an effective anti-inflammatory has disease-modifying properties in axSpA INTRODUCTION Spondyloarthritis (often shortened to SpA) is an umbrella term for several conditions that share many features and symptoms. These conditions include ankylosing spondylitis, psoriatic arthritis and reactive arthritis. Spondyloarthritis can be classified as axial or non-axial (peripheral), according to which joints in the […]
Category: TNF inhibitor
Predicting treatment success in rheumatoid arthritis
Particularly in early disease, prediction can be achieved for people with lower baseline levels of diseases activity INTRODUCTION Rheumatoid arthritis is a chronic inflammatory disease that affects a person’s joints, and may cause pain and disability. Rheumatoid arthritis can affect people of all ages, but it most often starts between the ages of 40 and […]
Treat-to-target is appropriate for women with RA during pregnancy
For women with rheumatoid arthritis, low disease and remission are an attainable goal during pregnancy INTRODUCTION Rheumatoid arthritis is a chronic inflammatory disease that affects a person’s joints, and may cause pain and disability. Rheumatoid arthritis can affect people of all ages, but it most often starts between the ages of 30 and 50 – […]
No significant difference between advanced therapies for RA
Individualised care should be based on clinical judgement and consideration of patient preferences. INTRODUCTION Rheumatoid arthritis is a chronic inflammatory disease that can affect a person’s joints, and may cause pain and disability. Rheumatoid arthritis affects people of all ages, and is more common in women than men. The goal of treatment is often remission […]
TNF inhibitors help reduce the change of ankylosis as well as improve symptoms
Compared to other treatments, TNF inhibitors slowed radiologic progression significantly. INTRODUCTION Ankylosing spondylitis is a chronic inflammatory disease. It mainly affects the joints in the spine, and the sacroiliac joint (in the back part of the pelvis), causing back pain and stiffness. Some changes in ankylosing spondylitis are very slow. For example, the destruction of […]
IL-17- or TNF inhibitors have comparable efficacy after failure of previous TNF inhibitors
Symptom relief and time on therapy are similar for people taking TNF inhibitors or secukinumab after previous TNF inhibitor failure. INTRODUCTION Spondyloarthritis (often shortened to SpA) is an umbrella term for several conditions that share many features and symptoms. These conditions include ankylosing spondylitis, psoriatic arthritis and reactive arthritis. Spondyloarthritis can be classified as axial […]
Managing axial spondyloarthritis
This is the lay version of the EULAR recommendations for the management of people with axial spondyloarthritis. The original publication can be downloaded from the EULAR website: www.eular.org. van der Heijde D, et al. 2016 update of the ASAS-EULAR management recommendations for axial spondyloarthritis. Ann Rheum Dis 2017;76:978–991. doi:10.1136/annrheumdis-2016-210770 Introduction EULAR recommendations give advice to […]
No increased risk of melanoma with TNF inhibitors
A large European collaborative project. INTRODUCTION Rheumatoid arthritis is a chronic inflammatory disease that affects a person’s joints, causing pain and disability. It can also affect internal organs. It is more common in older people, but there is also a high prevalence in young adults, adolescents and even children and affects both men and women. […]
Dose optimisation of TNF inhibitors results in considerable cost savings
TNF inhibitors are associated with long-term risks and high costs; improving how they are used is therefore important. INTRODUCTION Rheumatoid arthritis is a chronic inflammatory disease that affects a person’s joints and sometimes their internal organs, causing pain and disability. It is more common in older people, and affects both men and women. Adalimumab and […]
Women with rheumatoid arthritis and those treated with TNF inhibitors may be at increased risk of cervical cancer
Women with rheumatoid arthritis have a higher risk of cervical cancer, and those treated with TNF inhibitors have a further increased risk, though the link is not conclusive. INTRODUCTION Rheumatoid arthritis is a chronic inflammatory disease that affects a person’s joints, causing pain and disability. It can also affect internal organs. Rheumatoid arthritis is more […]
