This is the lay version of the EULAR recommendations for the non-drug management of people with systemic lupus erythematosus or systemic sclerosis – two conditions that fall under the umbrella definition of rheumatic diseases. The names are often shorted to SLE or just lupus instead of systemic lupus erythematosus, and scleroderma or SSc instead of […]
Category: Systemic sclerosis
Searching for new biomarkers in SSc-associated PAH
There are interesting proteins that could be used as biomarkers in people with PAH associated with systemic sclerosis Introduction Systemic sclerosis (SSc) is an autoimmune disease that causes abnormalities in the skin, joints, and internal organs, including the lungs. It is associated with changes in blood vessels and with scarring or thickening in affected tissues, […]
Nintedanib long-term safety data in people with interstitial lung disease
The safety profile of nintedanib was consistent with that reported in a previous trial Introduction Systemic sclerosis is an autoimmune disease that causes abnormalities in the skin, joints, and internal organs, including the lungs. It is associated with changes in blood vessels that causes scarring or thickening in affected tissues, such as the skin and […]
Progressive skin fibrosis is associated with decline in lung function and worse survival in people with dcSSc
Worsening skin disease could be used as a marker of internal organ damage in people with diffuse cutaneous subtype of systemic sclerosis (dcSSc). Introduction Systemic sclerosis is a rare but serious disease of the connective tissues, characterised by thickening of skin and by triggering the immune system to attack itself (autoimmunity). This can cause hardening […]
Immunosuppressant drugs may help in systemic sclerosis (dcSSc), but new treatments are needed
Immunosuppressants show some benefit in early dcSSc, but better treatments are still needed. INTRODUCTION Systemic sclerosis is a rare but serious disease of the connective tissues, where the tissue grows abnormally and triggers the immune system to attack itself (autoimmunity). This can cause hardening (fibrosis) and swelling of the skin, as well as joint pain, […]
Regression of skin fibrosis can be predicted using mRSS scores
People with advanced skin fibrosis are more likely to regress in the next year than those with milder skin fibrosis. INTRODUCTION Systemic sclerosis is a rare but serious disease of the connective tissue. An initial potential damage to the tissue due to yet unknown triggers causes the activation of the immune system (autoimmunity) and affects […]
Skin sclerosis and digital ulcers develop quickly in people with early systemic sclerosis
People with early systemic sclerosis may quickly develop skin sclerosis and digital ulcers. INTRODUCTION Systemic sclerosis is a rare but serious disease of the connective tissues, where the tissue grows abnormally and triggers the immune system to attack itself (autoimmunity). This can cause hardening (fibrosis) and swelling of the skin, as well as joint pain, […]
Ulcers on the fingers may predict disease worsening and survival in people with systemic sclerosis
People with digital ulcers early in the course of their systemic sclerosis may be more likely to suffer complications of the disease. INTRODUCTION Systemic sclerosis is a serious disease of the connective tissues, where the tissue grows abnormally and triggers the immune system to attack itself (autoimmunity). This can cause hardening (fibrosis) and swelling of […]
Patients with systemic sclerosis have a high risk of bone fractures
Patients with systemic sclerosis may be more likely to develop osteoporosis and experience bone fractures. INTRODUCTION Systemic sclerosis is a serious disease of the connective tissues, where the tissue grows abnormally and triggers the immune system to attack itself (autoimmunity). This can cause hardening (fibrosis) and swelling of the skin, as well as joint pain, […]
Rituximab may reverse fibrosis in patients with systemic sclerosis
Rituximab may offer a new treatment option in patients with systemic sclerosis. INTRODUCTION Systemic sclerosis is a serious disease of the connective tissues, where the tissue grows abnormally and triggers the immune system to attack itself (autoimmunity). This can cause hardening (fibrosis) and swelling of the skin, as well as joint pain, digestive problems and […]
